Manipulation of DNA - rupture forces.
Schematic of the manipulation performed:
This shows the tip path and the result of the manipulation in a 2D overhead
view:
This graph shows the lateral force measurements taken. The white halo around
the black curve are the actual measurements, which are quite noisy, but still
show the 500 pN force change when smoothed.
More details can be found in these references:
Guthold, M., Matthews, G., Negishi, A., Taylor, R. M., Erie, D., Brooks, F.
P. & Superfine, R. (1999). Quantitative Manipulation of DNA and Viruses with
the nanoManipulator Scanning Force Microscope. Surf. Interf. Analys. 27,
437-443
Guthold, M., Falvo, M. R., Matthews, W. G., Paulson, S., Washburn, S., Erie, D., Superfine, R., Brooks,
F. P. & Taylor, R. M. (2000). Controlled Manipulation of Molecular Samples with the
nanoManipulator.IEEE/ASME Transactions on Mechatronics. 5, 189-198
Guthold, M., Falvo, M., Matthews, W. G., Paulson, S., Mullin, J., Lord, S., Erie, D., Washburn, S.,
Superfine, R., Brooks, F. P. & Taylor, R. M. (1999). Investigation and Modification of Molecular Structures Using the NanoManipulator. J Mol. Graphics Mod. 17,
187-197
Images and scientific content are courtesy of the University of North Carolina at Chapel Hill.
